Finder Quick Look
Preview a molecular file without opening the full workspace.
Explore Burette
Explore structures.
Compare molecules.
Preview structures in Finder. Compare compounds, inspect a binding site,
or edit a molecule in the same Mac workspace.
01 / 09
Press Space. See the structure.
Start in Finder. Press Space to see what is inside a molecular file, then open the workspace when you want to keep working.
Interactive 3D
Rotate and zoom to inspect a structure from any angle.
Light and dark
Choose the background that makes your structure easiest to read.
Molecular thumbnails
Recognize supported structure files while browsing Finder.
Spectrum previews
Inspect supported mass spectra in a dedicated spectrum viewer.
02 / 09
From the whole protein to its ligand.
Show the protein fold, inspect a ligand, or hide water and focus on a single chain.
Illustrative appearance
Give molecular shapes clear outlines for readable figures.
Representation styles
Choose cartoons, sticks, spheres, or surfaces to suit the question.
Scene tree
Browse chains, ligands, water, and representations. Focus on one component or hide the parts you do not need.
Show, hide, isolate
Remove visual clutter while keeping the original structure available.
Colour controls
Colour components and adjust transparency without rebuilding your scene.
1 / 1
03 / 09
Pick a residue. Inspect its neighbours.
Select atoms in 3D or residues in the sequence, then measure distances or create a surface around your selection.
Ligand pockets
Show a pocket surface from protein residues within 5 Å of a ligand to inspect how their shapes fit together.
Measurements
Measure distances, angles, and dihedrals between selected atoms.
Sequence selection
Select a residue or range in the Sequence panel to highlight it in 3D.
Lasso selection
Draw around atoms to select part of a structure in 3D.
Surfaces for your selection
Create a surface for a residue, chain, protein, or ligand without covering the entire scene.
Extract a subset
Save the part of a structure you want to work with.
1 / 1
04 / 09
Watch a molecule move.
Play a trajectory or compare a set of molecular poses without leaving the viewer.
Trajectory playback
Play, pause, or step through individual frames while rotating the structure. The demo shows a 20-frame molecular vibration.
Pose alignment
Show every pose with All, then toggle Align to compare their overlap. Switch back to a single pose for a closer look.
SDF poses
Move between structures in a multi-record SDF, including V3000 files.
05 / 09
Find the compounds worth a closer look.
Browse structures and their properties together. Find a subset, inspect it, and export the result.
Substructure search
Use SMARTS to filter molecules and highlight matching atoms.
Cards and tables
Switch between molecular drawings and a property table.
Structures and properties
Select a molecule to see its drawing and descriptors beside the table. Filter numeric properties to narrow your collection.
Search, sort, and filter
Find a name or SMILES, sort a column, or narrow the table with a numeric property filter.
Open a molecule in its own tab
Move from a collection card to a full molecular view for rotation, selection, and inspection.
Selection and export
Select the compounds you want to keep, then export them as SMILES or CSV.
Browse large collections
Browse molecular cards as they load into view, without waiting for every drawing to render.
1 / 1
06 / 09
Find neighbours in chemical space.
Map a collection by molecular similarity and bring selected compounds back to the table. Native calculations run on Apple Silicon in the Mac app.
A map of your molecules
Explore molecular similarity in a 2D or 3D map, with each point representing a compound.
Linked selection
Select a region of the map and continue with those molecules in the grid.
Activity colouring
Colour a map by a numeric property to see how values vary.
Activity cliffs
Look for similar molecules with markedly different activity.
1 / 1
07 / 09
Explore different conformations.
Generate a set of 3D conformers and compare their shapes in the viewer.
Conformer generation
Generate 3D conformers from selected molecules or a Ketcher sketch.
08 / 09
Sketch, edit, and compare.
Edit a molecule in Ketcher, inspect its coordinates, and keep related files open in tabs and side panels.
Sketch to 3D
Open a Ketcher sketch as a 3D structure, then rotate it to inspect the geometry.
Project folders
Browse local project folders and files on a connected SSH host from the workspace sidebar.
Ketcher sketches
Work on molecular drawings in the integrated Ketcher editor.
Text editing
Inspect and edit supported molecular source files in place.
Tabs and docks
Keep structures, tables, text, and inspectors alongside one another.
Drag files into your workspace
Drop molecular files, collection records, or sketches into the workspace to continue working with them.
1 / 1
09 / 09
Connect your chemistry tools.
Work with an AI agent in Burette, or export a molecular figure for a paper.
Make a figure for your paper
Create molecular illustrations with the optional xyzrender engine. Export SVG artwork that stays sharp when resized for a paper or slide.
Work with your agent
Ask your agent to open a molecular file, inspect a structure, and use Burette workspace tools through MCP.
Video walkthrough coming soon.
Explore the agent tools ↗Bring your own files.
Free and open source. Made for your Mac.
Download Burette ↗